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Boosting Sirt4 gene activity extends healthy lifespan in fruit flies

A new study on the mechanics of aging and longevity finds that fruit flies inhibited from producing the protein Sirt4 — which is also found in humans — are short-lived, while flies modified to make extra Sirt4 are long-lived. In addition, flies lacking Sirt4 display increased sensitivity to starvation, decreased fertility …

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Cells protect genes more than rest of genome

Whilst DNA sequence mutation is the fundamental fuel of species evolution, mutations in genes are often harmful. As a form of defence, organisms have evolved repair mechanisms to correct the DNA sequence following mutation. One of these mechanisms, is termed DNA mismatch repair (MMR). It corrects mutations that arise during …

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DNA Mutations Shed in Blood Predicts Response to Immunotherapy in Patients with Cancer

In a first-of-its-kind study, University of California San Diego School of Medicine researchers report that a blood sample, or liquid biopsy, can reveal which patients will respond to checkpoint inhibitor-based immunotherapies. “We can help predict response to immunotherapy by measuring the number of mutations in circulating tumor DNA using a …

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Fast, noninvasive technique for probing cells may reveal disease

The stiffness or elasticity of a cell can reveal much about whether the cell is healthy or diseased. Cancer cells, for instance, are known to be softer than normal, while asthma-affected cells can be rather stiff. Determining the mechanical properties of cells may thus help doctors diagnose and track the …

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